One hundred and forty-two patients with carpal tunnel syndrome scheduled for an open carpal tunnel release were randomized to receive wound closure via the Donati suture technique (n=71) or the running subcuticular suture technique (n=71). The primary outcome of interest was scar assessment by the patient and physician via the Patient and Observer Scar Assessment Scale (POSAS). Secondary outcomes of interest included pain on a Verbal Numeric Rating Scale (NRS), function on the Boston Carpal Tunnel Questionnaire (BCTQ), grip strength, and pinch strength. Outcomes were assessed at 2 weeks, 6 weeks, and 12 weeks post-surgery. No significant differences were observed between groups in all outcomes at all time-points, with the exception of early (2 week) POSAS scores by the patient, which were in favour of the running subcuticular group.