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Peri-Operative

Remimazolam Besylate vs Dexmedetomidine for Sedation in Non-Intubated Geriatric Patients

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PERI-OPERATIVE

Remimazolam Besylate vs Dexmedetomidine for Sedation in Non-Intubated Geriatric Patients .

Efficacy and Safety of Remimazolam Besylate versus Dexmedetomidine for Sedation in Non-Intubated Older Patients with Agitated Delirium After Orthopedic Surgery: A Randomized Controlled Trial

Drug Des Devel Ther. 2022 Aug 1;16:2439-2451. doi: 10.2147/DDDT.S373772. eCollection 2022.. 2022 01-Aug;():. 10.2147/DDDT.S373772

Contributing Authors

Y Deng Z Qin Q Wu L Liu X Yang X Ju Y Zhang

Eighty geriatric patients with agitated delirium after orthopaedic surgery were randomized to receive remimazolam besylate (n=40) or dexmedetomidine (n=40) for the resolution of agitation. The primary outcome of interest was the time to resolution of agitation. Secondary outcomes of interest included sedation outcomes, length of stay, and adverse events, as well as vital signs and arterial blood gas analysis outcomes. Results revealed no difference in the time to delirium resolution between the two interventions. Remimazolam resulted in a quicker sedative effect, however, this resulted in a higher incidence of oversedation and a longer time to delirium solution. The rate of hypotension was significantly higher in the dexmedetomidine group.

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