Reduction in Odds of Pathological Fracture with Denosumab vs Zoledronic Acid for Bone Metastases
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Bisphosphonates Versus Denosumab for Prevention of Pathological Fracture in Advanced Cancers With Bone Metastasis: A Meta-analysis of Randomized Controlled Trials.
J Am Acad Orthop Surg Glob Res Rev. 2020 Aug; 4(8): e20.00045.Four studies including 7320 patients with bone metastases from advanced cancer were included in this meta-analysis comparing the likelihood of pathological fracture. Sub-group analyses were performed by tumour origin (endodermal cancer, mesodermal cancer). Pooled results found the likelihood of pathological fracture to be significantly lower in the denosumab group compared to the zoledronic acid group. However, in both sub-group analyses, no significant differences between treatments were observed in the pooled likelihood of pathological fracture in patients with endodermal cancer (breast and prostate) and mesodermal cancer (solid and multiple myeloma).
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