Psychological effects of (S)-ketamine and N,N-dimethyltryptamine (DMT): a double-blind, cross-over study in healthy volunteers

Este estudio ha sido identificado como potencialmente de alto impacto. La métrica de alto impacto de OE, basada en la inteligencia artificial, estima la influencia que puede tener un artículo integrando señales procedentes tanto de la revista en la que se publica como del contenido científico del propio artículo. Desarrollado mediante el procesamiento del lenguaje natural más avanzado, el modelo de Alto Impacto de OE predice con mayor precisión el futuro rendimiento de las citas de un estudio que el factor de impacto de la revista por sí solo. Esto permite reconocer antes las investigaciones clínicamente significativas y ayuda a los lectores a centrarse en los artículos con más probabilidades de configurar la práctica futura.

Resumen del estudio

Fifteen healthy subjects were included in this randomized, double-blind, crossover study comparing the psychological effects of serotonin 5HT-2A agonist N,N-dimethyltryptamine (DMT) and N-methyl-d-aspartate antagonist (NMDA) S-ketamine. Participants were administered low- and high-dose S-ketamine and DMT intravenously in a pseudorandomized order in two sessions with a washout period of 2 hours between doses and 2-4 weeks between sessions. Subjective drug effects were assessed using the Hallucinogen Rating Scale (HRS) and the Abnormer Psychischer Zustand (APZ) Altered States of Consciousness. Schizophrenia-like psychotic symptoms were assessed using three clinician rating scales: The Scale for the Assessment of Negative Symptoms (SANS), The Scale for the Assessment of Positive Symptoms (SAPS), and the Schizophrenia Prediction Instrument - Adult Version (SPI-A). The intensity of global psychological effect was similar for DMT and S-Ketamine. Positive symptoms of schizophrenia were more pronounced following DMT, whereas more negative symptoms were more pronounced after S-ketamine.