Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression .
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Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial
Psychol Med. 2019 23-Feb;():. 10.1017/S0033291718001356Twenty-nine patients with treatment-resistant depression were randomized to receive a single oral dose of ayahuasca containing 0.36 mg/kg of N, N-DMT or placebo in this randomized, double-blind, parallel-arm, placebo-controlled study examining the antidepressant effects of ayahuasca. The primary outcome was change in depression severity assessed by the Hamilton Depression Rating (HAM-D) scale from baseline to follow-up at day 7. The secondary outcome was change in Montgomery–Åsberg Depression Rating Scale (MADRS) scores from baseline to follow-up at day 1,2, and 7. Results show that ayahuasca had rapid and significant antidepressant effects at all time points compared to placebo. MADRS scores were significantly lower in the ayahuasca group com- pared with placebo at day 1,2 and 7.
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