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Based on the 5D-ASC, PY induced dose-dependent alterations of perception, affect, ego-functions, and attention in all subjects. The medium and high PY doses induced a loosening of ego-boundaries and complex visual hallucinations. Additionally, all subjects experienced general inactivation, introversion and dreaminess. One subject, after high-dose PY, experienced anxiety which plateaued after peak effects. Despite the increased hormone concentrations and moderate elevation in blood pressure, EKG and body temperatures were unaffected, providing evidence that PY is relatively safe to somatic health. The results are limited by the lack of using a higher dose of PY, as a higher dose was not chosen for safety reasons.