Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study
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OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(10):26 Psychopharmacology (Berl). 2004 23-Feb;():. 10.1007/s00213-003-1640-6Study Summary
Eight healthy subjects underwent a double-blind, placebo-controlled study to test the dose-dependent effects of psilocybin (PY) on psychological and physiological outcomes. Subjects randomly received a placebo, very low dose, low dose, medium dose and high dose of PY. Outcome measures included psychological core dimensions (using the 5D-ASC), attention, mood and plasma concentrations of hormones such as TSH, PRL, CORT and ACTH. In a dose-dependent manner, PY increased scores on the 5D-ASC, decreased attention scores, and increased scores of emotional excitability and dreaminess. After the high dose, PY increased plasma levels of all hormones.
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