Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(10):26 Psychopharmacology (Berl). 2004 23-Feb;():. 10.1007/s00213-003-1640-6What this means for my practice?
Based on the 5D-ASC, PY induced dose-dependent alterations of perception, affect, ego-functions, and attention in all subjects. The medium and high PY doses induced a loosening of ego-boundaries and complex visual hallucinations. Additionally, all subjects experienced general inactivation, introversion and dreaminess. One subject, after high-dose PY, experienced anxiety which plateaued after peak effects. Despite the increased hormone concentrations and moderate elevation in blood pressure, EKG and body temperatures were unaffected, providing evidence that PY is relatively safe to somatic health. The results are limited by the lack of using a higher dose of PY, as a higher dose was not chosen for safety reasons.
Study Summary
Eight healthy subjects underwent a double-blind, placebo-controlled study to test the dose-dependent effects of psilocybin (PY) on psychological and physiological outcomes. Subjects randomly received a placebo, very low dose, low dose, medium dose and high dose of PY. Outcome measures included psychological core dimensions (using the 5D-ASC), attention, mood and plasma concentrations of hormones such as TSH, PRL, CORT and ACTH. In a dose-dependent manner, PY increased scores on the 5D-ASC, decreased attention scores, and increased scores of emotional excitability and dreaminess. After the high dose, PY increased plasma levels of all hormones.
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