Psilocybin-assisted mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(10):17 Neuroimage. 2019 14-Feb;():. 10.1016/j.neuroimage.2019.04.009What this means for my practice?
Psilocybin can potentially induce changes in the self-referential processing networks which lead to positive psycho-social outcomes. Psilocybin induced the decoupling of the medial prefrontal and posterior cingulate cortices, which are thought to mediate the sense of self. The decoupling was associated with the subjective ego dissolution effect during the mindfulness session and both changes predicted positive psycho-social outcomes after four months. These results are limited by the low sample size and the bias of subjects' experience in experiencing altered states of consciousness through meditation.
Study Summary
Thirty-eight healthy, experienced meditators underwent a between-subjects, double-blind, randomized, placebo-controlled study to test the effects of psilocybin, combined with meditation on self-referential processing networks (which include the medial prefrontal and posterior cingulate cortices) in the default mode network (DMN) of the brain. The psilocybin was given to the meditators on the fourth day of a five day mindfulness retreat. fMRI scans were collected during the resting state, focused attention and open awareness stages of the meditation practice. Combined with meditation, psilocybin induces functional connectivity changes in self-referential processing networks.
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