Platelet-Rich Plasma Versus Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-analysis of 26 Randomized Controlled Trials

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

Twenty-six randomized controlled trials including 2430 adults with knee osteoarthritis (OA) were included in this meta-analysis comparing platelet-rich plasma (PRP) injections and hyaluronic acid (HA) injections for the relief of symptoms. Pooled outcomes of interest included the incidence of adverse events, the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index, pain, stiffness, and physical function scores, pain scores on a Visual Analogue Scale (VAS), Euro-QoL scores on a VAS (EQ-VAS), International Knee Documentation Committee (IKDC) scores, Tegner activity scores, Lequesne scores, Knee Injury and Osteoarthritis Outcomes Scores (KOOS) for pain, symptoms, daily activity, sport, and quality of life, and patient satisfaction. In addition, WOMAC scores, VAS scores, EQ-VAS scores and IKDC scores were pooled at 1, 3, 6 and 12 months post-treatment, whilst Tegner scores and KOOS scores were pooled at 2, 6 and 12 months post-treatment. Adverse events and satisfaction at final follow-up were pooled. Pooled results revealed statistically significantly favourable WOMAC total scores, WOMAC physical function scores, and VAS pain scores in the PRP group compared to the HA group at 3, 6 and 12 months post-treatment (p<0.05 for all). Pooled WOMAC pain scores, WOMAC stiffness scores, EQ-VAS scores, and IKDC scores were statistically significantly in favour of the PRP group at 6 and 12 months post-treatment (p<0.05 for all). Moreover, pooled Tegner scores at 12 months were statistically in favour of the PRP group (p=0.04). In the remaining pooled outcomes, no statistical significant differences were observed between the two groups.