Polyacrylamide gel versus Hyaluronic Acid for the Treatment of Pain in Knee Osteoarthritis .
Polyacrylamide gel versus hyaluronic acid for the treatment of knee osteoarthritis: a randomised controlled study.
Clin Exp Rheumatol . 2024 Sep;42(9):1729-1735.Two hundred thirty-nine adults with symptomatic and radiographic knee osteoarthritis were randomized to receive a single intra-articular injection of polyacrylamide hydrogel (n=119) or hyaluronic acid (n=120). The primary outcome was the change in the WOMAC pain subscale at 26 weeks. Secondary outcomes included changes in WOMAC stiffness and physical function, patient global assessment, EQ-5D-5L health state, and OMERACT-OARSI response rates at 26 and 52 weeks. Outcomes were assessed up to 1 year. Overall, the results demonstrated that iPAAG was non-inferior to HA in reducing pain and improving symptoms. The study concluded that iPAAG is an effective and safe alternative to HA for knee osteoarthritis treatment.
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