Platelet-Rich Plasma Injections for Knee Osteoarthritis .
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Intra-articular injections of platelet-rich plasma decrease pain and improve functional outcomes than sham saline in patients with knee osteoarthritis
Knee Surg Sports Traumatol Arthrosc . 2022 Dec;30(12):4063-4071.Six hundred and forty-four patients with knee osteoarthritis (OA) were randomized to receive either platelet-rich plasma (PRP; n=322) or sham saline solution (n=322). Outcomes of interest were the Western and McMaster Universities Osteoarthritis Index (WOMAC) pain, stiffness, function subscales and an overall score, International Knee Documentation Committee (IKDC) score, Visual Analog Scale pain, and levels of tumor necrosis factor-alpha (TNF-a), interleukin-1B (IL-1B), and cartilage volume. The PRP group has significantly better WOMAC, IKDC, and pain scores at all time points (3, 6, 12, 24, and 60 months).
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