The Effect of Perioperative Corticosteroids in Total Hip Arthroplasty: A Prospective Double-Blind Placebo Controlled Pilot Study

この研究はハイインパクトの可能性があります。 OEのAI駆動型ハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文が持つ可能性の高い影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することが可能になり、読者は将来の診療を形成する可能性が最も高い論文に集中することができます。

40 patients undergoing total hip arthroplasty were randomized to undergo the procedure with or without perioperative administration of corticosteroids (oral prednisone and intravenous hydrocortisone). The purpose of this study was to determine if perioperative corticosteroid resulted in significantly different serum concentrations of prothrombin fragment 1.2 (PF1.2), plasmin-alpha-2-antiplasmin (PAP) and, interkeukin-6 (IL-6). Additionally, differences in pain, analgesic consumption, and patient function performance were evaluated during initial hospital stay and at 3-months post-surgery. Results demonstrated comparable serum concentrations of PF1.2 and PAP at all follow-up points. Significantly reduced concentrations of IL-6 at 6 and 24 hours, maximum pain scores on postoperative day 0, and total patient-controlled analgesia volume was observed in the corticosteroid group. All other comparisons, including those evaluated at 3 months, were comparable between groups.