40 patients undergoing total hip arthroplasty were randomized to undergo the procedure with or without perioperative administration of corticosteroids (oral prednisone and intravenous hydrocortisone). The purpose of this study was to determine if perioperative corticosteroid resulted in significantly different serum concentrations of prothrombin fragment 1.2 (PF1.2), plasmin-alpha-2-antiplasmin (PAP) and, interkeukin-6 (IL-6). Additionally, differences in pain, analgesic consumption, and patient function performance were evaluated during initial hospital stay and at 3-months post-surgery. Results demonstrated comparable serum concentrations of PF1.2 and PAP at all follow-up points. Significantly reduced concentrations of IL-6 at 6 and 24 hours, maximum pain scores on postoperative day 0, and total patient-controlled analgesia volume was observed in the corticosteroid group. All other comparisons, including those evaluated at 3 months, were comparable between groups.