ARTHROPLASTY
Peri-articular steroid injection improves the outcome after unicondylar knee replacement- A PROSPECTIVE, RANDOMISED CONTROLLED TRIAL WITH A TWO-YEAR FOLLOW-UP
This report has been verified
by one or more authors of the
original publication.
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これにより、臨床的に意義のある研究をより早く認識することが可能になり、読者は将来の診療を形成する可能性が最も高い論文に集中することができます。
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2013;1(2):60 J Bone Joint Surg Br. 2008 Jun;90(6):738-4490 patients undergoing medial unicondylar knee replacement (UKR) were randomized to receive a peri-articular injection of a mixture containing bupivacaine and epinephrine with or without a corticosteroid intraoperatively. The peri-articular injection containing the corticosteroid improved pain relief at 12,18 and 24 hours and allowed for rehabilitation benefits with no increase in the risk of infections.
Was the allocation sequence adequately generated?
Was allocation adequately concealed?
Blinding Treatment Providers: Was knowledge of the allocated interventions adequately prevented?
Blinding Outcome Assessors: Was knowledge of the allocated interventions adequately prevented?
Blinding Patients: Was knowledge of the allocated interventions adequately prevented?
Was loss to follow-up (missing outcome data) infrequent?
Are reports of the study free of suggestion of selective outcome reporting?
Were outcomes objective, patient-important and assessed in a manner to limit bias (ie. duplicate assessors, Independent assessors)?
Was the sample size sufficiently large to assure a balance of prognosis and sufficiently large number of outcome events?
Was investigator expertise/experience with both treatment and control techniques likely the same (ie.were criteria for surgeon participation/expertise provided)?
はい = 1
不確実＝0.5
無関係 = 0
いいえ = 0
報告基準評価では、著者が出版物内で試験の方法論的特徴や試験特性を報告する際の透明性を評価します。評価は以下の5つのカテゴリーに分類されます。
4/4
Randomization
3/4
Outcome Measurements
4/4
Inclusion / Exclusion
4/4
Therapy Description
3/4
Statistics
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
Fragility Indexは、重要な所見の解釈を助けるツールで、結果の強さの尺度を提供します。Fragility Indexは、その所見が有意でなくなるために、二項対立の結果に追加する必要がある連続した事象の数を表します。数値が小さいほど弱い所見を表し、数値が大きいほど強い所見を表します。
なぜ今この研究が必要なのですか？
Local injection of corticosteroids has been used extensively in chronic, inflammatory or painful musculoskeletal tissues and joints, without the impairment of wound healing or any overt complications. As meticulous management of post-operative pain is required for effective rehabilitation after knee arthroplasty, corticosteroids may be a possible treatment option as a part of a multimodal analgesic regime. Thus, this study aimed to evaluate the safety and efficacy of a peri-articular steroid injection for pain control following unicondylar knee replacement for medial compartment arthritis.
主な研究課題は何ですか？
Is an intraoperative peri-articular injection of triamcinolone acetonide in patients undergoing medial unicondylar knee replacement a safe and effective option for improving clinical outcomes?
重要な知見は？
- Preoperative clinical details were similar between both groups (p>0.05)
- Study group reported a significant reduction in pain (p=0.014 at 12 hours, p=0.031 at 18 hours and p=0.031 at 24 hours)
- Mean morphine consumption was less in the study group compared to control group in the initial 24 hours
- Study group had a better range of movement than the control group during early follow-ups and this was continued at the 3 month time point (p=0.023)
- The study group had a significantly lower mean decrease in haemoglobin level (p=0.028)
- Study group was able to perform a SLR significantly earlier than the control group (p=0.019)
- There were no significant differences in the rates of infection (p=0.382) and no incidence of tendon rupture in either of the groups
最も覚えておくべきことは？
The intraoperative peri-articular injection of a mixture of corticosteroid, bupivacaine and epinephrine during unicondylar knee replacement surgery provided improved pain relief and quicker rehabilitation benefits with no increase in the risk of infections.
それが私の患者ケアにどのように影響するか？
Triamcinolone may be a valuable component for the peri-articular infiltration along with the standard local anesthetics for better post-operative analgesia in the short term and overall rehabilitation in the long term. Future trials should involve larger sample sizes for further evaluation and validation of these findings.
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