Periarticular and intravenous TXA comparable in blood loss and transfusion rates after TKA .
Peri-articular tranexamic acid injection in total knee arthroplasty: a randomized controlled trial
BMC Musculoskelet Disord. 2016 Jul 26;17:313.60 patients scheduled for unilateral total knee arthroplasty were randomized to be administered either periarticular or intravenous tranexamic acid (TXA). The purpose of this study was to compare blood loss and adverse events throughout the first 48-hours post-surgery. The results from this trial demonstrated non-significant differences between groups for postoperative blood loss volume, hematocrit levels, hemoglobin concentration, the number of patients requiring transfusion, VAS pain scores, and thigh/leg circumference when evaluated at 24- or 48-hours postoperatively.
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