Patient-reported outcomes and complications of a new-generation total knee system: a randomized controlled trial.
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2025;13(7):7 Acta Orthop. 2025 Feb 25;96:195–202.What this means for my practice?
This study demonstrates that the Persona and NexGen total knee systems provide equivalent short-term patient-reported outcomes and complication rates following knee arthroplasty. These findings support the clinical interchangeability of the two systems in early postoperative care. However, limitations include limited power for detecting rare complications and lack of long-term outcome data.
Study Summary
Three hundred fourteen patients with primary osteoarthritis undergoing total knee arthroplasty were randomized to receive either the Persona (n=157) or NexGen (n=157) cruciate-retaining total knee arthroplasty system. The primary outcome of interest was the Oxford Knee Score (OKS) at 2 years post-surgery. Secondary outcomes included the Oxford Knee Score Activity and Participation Questionnaire (OKS-APQ), Forgotten Joint Score (FJS), EQ-5D-3L index and VAS, and the number of complications. Outcomes were assessed at 3 months, 1 year, and 2 years. Overall, the results of the study revealed no statistically or clinically significant differences in the OKS or any secondary patient-reported outcomes between the groups. The findings suggest that the short-term performance and safety of the Persona system are comparable to the NexGen system.
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