Palonosetron vs. Granisetron for Chemotherapy-Induced Nausea and Vomiting in Pediatric Osteosacroma .
Does a single dose of palonosetron have any role in preventing acute chemotherapy-induced nausea and vomiting in pediatric osteosarcoma patients without dexamethasone? A randomized clinical trial
Adv Clin Exp Med. 2022 01-Mar;():. 10.17219/acem/142332200 pediatric osteosarcoma patients were randomized to receive a single intravenous dose of palonosetron or granisetron for antiemetic prophylaxis. The primary outcome was patient response to treatment in the first 24 hours after chemotherapy (complete response; partial response; failure). Adverse events were also recorded. Results found that patients who received palonosetron had a significantly greater treatment response vs. patients who received granisetron. No serious treatment-related adverse events were reported.
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