Pain reduction greater with 5 injections of high-dose HA vs control for plantar fasciopathy .
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Short-term efficacy and safety of hyaluronic acid injection for plantar fasciopathy
Knee Surg Sports Traumatol Arthrosc. 2018 Mar;26(3):903-911168 patients with plantar fasciopathy were randomized to weekly injections of high-dose hyaluronic acid (25mg), low-dose hyaluronic acid (8mg), or control, very low-dose hyaluronic acid (HA) (0.25mg), for 5 weeks. Patients were assessed for reduction in visual analog scale pain (VAS pain) from baseline to 5 weeks, as well as incidence of improvement in function, local symptoms, and activities of daily living after 5 weeks. Results demonstrated a significantly greater reduction in VAS pain from baseline to 5 weeks in the high-dose HA group compared to the control group, but not the low-dose HA group compared to the control group. The incidences of improvement in function, local symptoms, and activities of daily living after 5 weeks did not significantly differ between the three groups.
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