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Previous Ace Report OTA 2022: Multimodal Pain Protocol vs Hydrocodone-Acetaminophen Next Ace Report Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate for Tibial Fractures
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OTA 2022: Preoperative Aqueous Antiseptic Skin Solutions for Open Fractures
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OTA 2022: Preoperative Aqueous Antiseptic Skin Solutions for Open Fractures

Aqueous-PREP: A Pragmatic Randomized Trial Evaluating Preoperative Aqueous Antiseptic Skin Solutions in Open Fractures

Contributing Authors

Investigators PREP-IT Gerard Slobogean

1640 patients receiving surgical fixation for open extremity fractures were randomized to receive either 10% povidone-iodine or 4% chlorhexidine gluconate (CHG) for antiseptic skin preparation. The primary outcome of this trial was surgical-site infection and the secondary outcome was unplanned fracture-related reoperation within 1 year. Results revealed no significant differences in all outcomes between the two aqueous-based solutions.

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OrthoEvidence. OTA 2022: Preoperative Aqueous Antiseptic Skin Solutions for Open Fractures. ACE Report. 2025;312(1):4. Available from: https://myorthoevidence.com/AceReport/Show/ota-2022-preoperative-aqueous-antiseptic-skin-solutions-for-open-fractures

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