Osteosarcoma: 25 year survival rate significantly improved with adjuvant chemotherapy .
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Long-term results (>25 years) of a randomized, prospective clinical trial evaluating chemotherapy in patients with high-grade, operable osteosarcoma
Cancer. 2012 Dec 1;118(23):5888-9359 patients who underwent treatment for stage IIA/IIB, intramedullary, high-grade osteosarcoma, between 1981 and 1984, were randomized to receive either T-10B protocol adjuvant chemotherapy or no adjuvant chemotherapy following definitive surgical resection. Improvements in disease-free survival (DFS) and overall survival (OS) were monitored over 25 years, and tumor necrosis was evaluated for implications in prognosis. Results demonstrated a significant improvement in DFS and OS in patients who received adjuvant chemotherapy.
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