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Optimal doses of TENS, EA or LLLT provides short-term pain relief for knee osteoarthritis
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OSTEOARTHRITIS
Optimal doses of TENS, EA or LLLT provides short-term pain relief for knee osteoarthritis .

OrthoEvidence Journal (OE Journal) - ACE Report

OE Journal. 2013;1(11):187 BMC Musculoskelet Disord. 2007 Jun 22;8:51

This systematic review with meta-analysis for 36 randomized placebo-controlled trials looked at the efficacy of physical modalities (transcutaneous electrical stimulation - TENS, electro-acupuncture - EA, pulsed electromagnetic fields - PEMF, ultrasound - US, and low level laser treatment - LLLT) in patients with knee osteoarthritis (OA) pain within 1-4 weeks and at follow-up at 1-12 weeks after the treatment. The 36 RCTs identified had 2434 patients with a mean age of 65.1 years (1391 patients received active treatment). Results indicated that the optimal doses of TENS, EA and LLLT appear to offer short-term pain relief for knee OA.


Détails du financement de la publication +
Financement:
Non-Industry funded
Sponsor:
Norwegian Research Council
Conflits:
None disclosed

Risque de partialité

10/10

Critères de déclaration

17/20

Indice de fragilité

N/A

Were the search methods used to find evidence (original research) on the primary question or questions stated?

Was the search for evidence reasonably comprehensive?

Were the criteria used for deciding which studies to include in the overview reported?

Was the bias in the selection of studies avoided?

Were the criteria used for assessing the validity of the included studies reported?

Was the validity of all of the studies referred to in the text assessed with use of appropriate criteria (either in selecting the studies for inclusion or in analyzing the studies that were cited)?

Were the methods used to combine the findings of the relevant studies (to reach a conclusion) reported?

Were the findings of the relevant studies combined appropriately relative to the primary question that the overview addresses?

Were the conclusions made by the author or authors supported by the data and or analysis reported in the overview?

How would you rate the scientific quality of this evidence?

Oui = 1

Incertain = 0,5

Non pertinent = 0

Non = 0

L'évaluation des critères de rapport permet d'évaluer la transparence avec laquelle les auteurs rapportent les caractéristiques méthodologiques et les caractéristiques de l'essai dans la publication. L'évaluation est divisée en cinq catégories qui sont présentées ci-dessous.

4/4

Introduction

3/4

Accessing Data

4/4

Analysing Data

3/4

Results

3/4

Discussion

Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65

L'indice de fragilité est un outil qui aide à l'interprétation des résultats significatifs, en fournissant une mesure de la force d'un résultat. L'indice de fragilité représente le nombre d'événements consécutifs qui doivent être ajoutés à un résultat dichotomique pour que le résultat ne soit plus significatif. Un petit nombre représente un résultat plus faible et un grand nombre un résultat plus fort.

Pourquoi cette étude était-elle nécessaire maintenant ?

The most common type of osteoarthritis (OA) is osteoarthritis of the knee. It is associated with pain and inflammation, loss of function, impaired muscle stabilization and reduced range of motion. There is uncertainty on the efficacy of non-pharmacological physical modalities on knee osteoarthritis pain. This systematic review and meta-analysis was needed to examine the short-term effects of physical modalities on OA pain.

Quelle était la principale question de recherche ?

Does the use of physical modalities (transcutaneous electrical stimulation, electro-acupuncture, pulsed electromagnetic fields, ultrasound, low level laser treatment) offer clinically significant short-term pain relief for individuals with knee osteoarthritis?

Caractéristiques de l'étude +
Source des données:
A search was conducted for randomized controlled trials using the online databases from 1966 to April 2006 on Medline, Embase, Cochrane Controlled Trials Register for RCTs, CINAHL, Database of Abstracts of Reviews of Effectiveness (DARE), International Network of Agencies for Health Technology Assessment (INAHTA) database, The Physiotherapy Evidence Database (PEDro), National Guideline Clearinghouse (NGC), PRODIGY Guidance, and NICE (National Institute for Clinical Excellence). Hand searches were also performed in the journal Laser Therapy from 1994, national Scandinavian physiotherapy journals, conference abstracts and reference lists of systematic reviews and books of abstracts after 1990 by the World Confederation of Physical Therapy and World Association for Laser Therapy. Finally, experts in the field were also consulted.
Termes de l'index:
"Osteoarthritis OR osteoarthrosis OR knee OR exercise OR electrotherapy OR laser therapy OR light therapy OR ultrasound OR electrostimulation OR transcutaneous electrical nerve stimulation OR electromagnetic AND randomized OR randomised"
Sélection de l'étude:
Studies included were randomized, placebo-controlled trials where patients underwent treatment for knee osteoarthritis (OA) with specified interventions. The specific inclusion criteria included 1. A diagnosis of knee osteoarthritis, 2. Symptom duration of >3 months, 3. Randomised blinded placebo-controlled parallel and cross-over groups trial design, 4. Outcome measures of pain intensity within 4 weeks of treatment start (primary) and 5 to 12 weeks follow-up (secondary), 5. Threshold levels for clinical relevance and 6. Intervention groups which included criteria for modality-specific optimal dosage (Acupuncture, low level laser therapy (LLLT), pulsed electromagnetic fields (PEMF), including shortwave therapy (SWT), PEMF other than SWT, electrical stimulation using surface electrodes (TENS), ultrasound therapy, static magnets, and placebo control groups). Two independent reviewers (JMB and RABL-M) assessed trial methodology. 36 trials investigating a total of 2434 patients (1391 actively treated) were selected.
Extraction des données:
The change in overall pain intensity between the active intervention group and placebo was used, however, if more than one attainable outcome measurement was obtained in the first 4 weeks after treatment started, the time point corresponding to the largest effect values was selected. If the aforementioned data was missing, data were obtained as a mean of the 5 items on the WOMAC pain subscale, or were converted to 100 mm VAS and checked against other subscales and overall WOMAC score.
Synthèse des données:
Outcomes were expressed as weighted mean differences (WMD) between the intervention and placebo groups with 95% confidence interval in the VAS scores. A fixed effects model was used. Q-values were used to test heterogeneity, and statistical significance for each intervention was defined at the 0.05. Revman 4.2 software package was used for statistical analysis.
Quels sont les résultats importants ?
  • Clinically relevant pain-relieving effects were seen with the use of transcutaneous electrical nerve stimulation (TENS) (18.8 mm [95% CI: 9.6 to 28.1]) (n=414), electro-acupuncture (EA) (21.9 mm [95%CI: 17.3 to 26.5]) (n=73) and low level laser therapy (LLLT) (17.7 mm [95% CI: 8.1 to 27.3]) (n=343) measured by VAS compared to the placebo.
  • When a subgroup analysis of trials was performed with assumed optimal doses, an increase in efficacy was seen. TENS had an increase to 22.2 mm [95%CI: 18.1 to 26.3], LTT had an increase to 24.2 mm [95%CI: 17.3 to 31.3] on VAS.
  • A small reduction in pain was seen when pulsed electromagnetic fields were used measured by VAS. (6.9 mm [95%CI: 2.2 to 11.6]) (n=487)
  • No statistically significant reduction in short-term pain was seen over the placebo at 4 weeks from the treatments of manual acupuncture, static magnets, and ultrasound therapies (p>0.05).
  • There was minimal follow-up data up to 12 weeks, but the outcome effects of TENS, EA, and LLLT seemed to persist for at least 4 weeks after the treatments ended.
  • The mean methodological quality scores over all the included trials was 3.8 out of a score of 5 on the Jadad scale.
De quoi dois-je me souvenir en priorité ?

The use of transcutaneous electrical nerve stimulation (TENS), electro-acupuncture (EA), and low level laser therapy (LLLT) at optimum doses in an intensive 2-4 week treatment program appeared to produce clinically relevant short-term pain relief in patients with knee osteoarthritis.

Comment cela affectera-t-il les soins prodigués à mes patients ?

Patients may find short-term pain relief from knee OA when they undergo a regimen of TENS, EA or LLLT. These physical therapies also appear to be a safe method of pain management for knee OA as no serious adverse events were reported in the RCTs reviewed. Based on this study, MA, PEMF, US and SM can not be recommended due to lack of efficacy on short-term pain relief for knee OA. Further high quality evidence is needed to support these findings.

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OrthoEvidence. Optimal doses of TENS, EA or LLLT provides short-term pain relief for knee osteoarthritis. OE Journal. 2013;1(11):187. Available from: https://myorthoevidence.com/AceReport/Show/optimal-doses-of-tens-ea-or-lllt-provides-short-term-pain-relief-for-knee-osteoarthritis

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