An Opioid-Free Perioperative Pain Protocol Is Noninferior to Opioid-Containing Management: A Randomized Controlled Trial.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

Three hundred fifteen patients undergoing five common elective orthopedic procedures were randomized to receive either an opioid-free perioperative pain management protocol (n=157) or an opioid-containing protocol (n=158). The primary outcome was the numeric rating scale (NRS) for pain at 24 hours postoperatively. Secondary outcomes included pain levels at other time points (6 and 12 hours; 2 weeks, 6 weeks, and 1 year), comfort, opioid consumption, patient-reported outcomes, and adverse events. Outcomes were assessed up to 1 year post-surgery. Overall, the results revealed that the opioid-free protocol was noninferior to the opioid-containing protocol for pain at 24 hours. Pain levels were significantly lower in the opioid-free group at 12 hours and 2 weeks. The opioid-free group also reported better comfort at 24 hours and greater satisfaction with pain control at 6 weeks. No significant differences in adverse events or readmissions were observed. These findings suggest that an opioid-free protocol can safely and effectively manage pain in the perioperative setting for orthopedic procedures.