Effect of Platelet-Rich Plasma on Nonsurgically Treated Acute Achilles Tendon Ruptures: A Randomized, Double-Blinded Prospective Study.

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研究概要

Thirty-eight males with Achilles tendon ruptures (ATRs) were randomized into receiving Platelet-Rich Plasma (PRP) or a sham injection of isotonic saline. The primary outcome of interest included self-reported Achilles Tendon Rupture Score (ATRS) which was measured at 8 weeks, 3, 4.5-5, 6, 9, and 12 months follow-up. The secondary outcomes of interest included the following measures: 1-leg heel-rise work, heel-rise height, Achilles tendon length, calf circumference, and range of motion ankle dorsiflexion. Furthermore, time to return to running and the incidence of patients returning to pre-injury levels of sports activity was recorded. The results demonstrated that there were no statistically significant differences between groups in all outcomes at all time-points. The mean time to return to running was shorter in the PRP group (21 weeks) compared to the sham (23 weeks). Moreover, more patients returned to pre-injury levels of sports activity in the PRP group (32%) compared to the sham (26%).