Effect of Platelet-Rich Plasma on Nonsurgically Treated Acute Achilles Tendon Ruptures: A Randomized, Double-Blinded Prospective Study.
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2020;8(16):4 Am J Sports Med. 2020 Jul;48(9):2268-2276.What this means for my practice?
The results revealed that PRP did not significantly improve functional and clinical outcomes compared to the sham group. Thus, this study supports that PRP treatment does not significantly improve outcomes in individuals with Achilles tendon rupture injuries.
Study Summary
Thirty-eight males with Achilles tendon ruptures (ATRs) were randomized into receiving Platelet-Rich Plasma (PRP) or a sham injection of isotonic saline. The primary outcome of interest included self-reported Achilles Tendon Rupture Score (ATRS) which was measured at 8 weeks, 3, 4.5-5, 6, 9, and 12 months follow-up. The secondary outcomes of interest included the following measures: 1-leg heel-rise work, heel-rise height, Achilles tendon length, calf circumference, and range of motion ankle dorsiflexion. Furthermore, time to return to running and the incidence of patients returning to pre-injury levels of sports activity was recorded. The results demonstrated that there were no statistically significant differences between groups in all outcomes at all time-points. The mean time to return to running was shorter in the PRP group (21 weeks) compared to the sham (23 weeks). Moreover, more patients returned to pre-injury levels of sports activity in the PRP group (32%) compared to the sham (26%).
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