No Difference Between Intravenous and Oral Pre-operative Acetaminophen in Outpatient Surgery .
Preoperative Intravenous Versus Oral Acetaminophen in Outpatient Surgery: A Double-Blinded, Randomized Control Trial
J Perianesth Nurs. 2021 Apr;36(2): 162-166.One hundred and twenty adults scheduled for an outpatient surgery were randomized to receive 1,000 mg of pre-operative intravenous acetaminophen (n=60) or oral acetaminophen (n=60) for post-operative pain relief. Outcomes of interest included the worst post-operative pain on a Numeric Rating Scale, incidence of opioid use, post-operative opioid consumption (in morphine milligram equivalents), the incidence of nausea, vomiting, and low O2 saturation, use of reversal agents, length of stay in the post-anesthesia care unit, and patient satisfaction with pain control. Results revealed no significant differences between the two groups in all outcomes (p>0.05 for all).
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