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Clinicians should remember that while NMES can be beneficial for pain relief in some knee osteoarthritis cases, its combination with exercise does not significantly improve pain outcomes compared to exercise alone. This suggests that while NMES can be included in treatment plans, reliance solely on this intervention to improve clinical outcomes may be unfounded. The study also notes the limitations in the existing evidence, particularly the high risk of bias across studies and the variability in NMES applications, which could affect the generalizability of the findings. Therefore, more robust clinical trials are needed to definitively ascertain the role of NMES in managing knee osteoarthritis.