Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):11 Eur Neuropsychopharmacol. 2020 23-Feb;():. 10.1016/j.euroneuro.2020.10.002What this means for my practice?
Low doses of LSD can induce selective, beneficial effects on mood and cognition. At the minimal dose (5 mcg), beneficial effects such as increased friendliness, arousal, and decreased attentional lapses were observed. More apparent effects were observed at 20 mcg, such as increased positive mood, friendliness and increased attentional focus. Negative effects such as anxiety and confusion were also observed. The results are limited by the small sample size.
Study Summary
Twenty-four healthy subjects underwent a double-blind, placebo-controlled, within-subject study to test the minimal dose of LSD needed to affect mood and cognition. Subjects received 5, 10 or 20 mcg of LSD and measures of cognition, mood and subjective experience were taken up until 6 hours after administration. LSD induced positive effects such as increasing positive mood (20 mcg), friendliness (5, 20 mcg), arousal (5 mcg), and decreasing attentional lapses (5, 20 mcg). LSD induced negative effects such as an increase in confusion (20 mcg) and anxiety (10, 20 mcg). The minimal LSD dose where subjective and performance effects were apparent was 5 mcg.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
Are you affiliated with one of our partner associations?
Click here to gain complimentary access as part your association member benefits!
0 of 4 monthly FREE articles unlocked
