Modulating the rate and rhythmicity of perceptual rivalry alternations with psilocybin. .
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Modulating the rate and rhythmicity of perceptual rivalry alternations with the mixed 5-HT2A and 5-HT1A agonist psilocybin
Neuropsychopharmacology. 2005 23-Feb;():. 10.1038/sj.npp.1300621Twelve healthy subjects underwent a double-blind, placebo-controlled, within-subject study design to test the effects of psilocybin on binocular rivalry and perceptual switching. In a counterbalanced order, subjects received a placebo, a low-dose of psilocybin (115 microg/kg) and a high dose (250 microg/kg) on three days separated by two weeks. At the peak of drug action, the rate and rhythmicity of perceptual alternations were significantly reduced compared to placebo levels. After the peak of drug action, the perceptual switch rate successively increased. These changes in rivalry phase durations paralleled changes in psychological state as measured by the 5D-ASC.
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