Manipulation from 1-7 days after CCH injection is feasible for Dupuytren contractures .
Prospective Randomized Controlled Trial Comparing 1- Versus 7-Day Manipulation Following Collagenase Injection for Dupuytren Contracture
J Hand Surg Am. 2014 Oct;39(10):1933-1941.e1. doi: 10.1016/j.jhsa.2014.07.010. Epub 2014 Sep 4.43 patients (46 digits) with Dupuytren contracture were randomly allocated to undergo manipulation at 1 or 7 days after collagenase Clostridium histolyticum (CCH) injection, with the purpose of comparing the efficacy and side effects of postponing manipulation. At 30 days follow-up, the efficacy of CCH was preserved in the 7-day manipulation group, suggesting manipulation can be scheduled at the convenience of the patient and surgeon within the first 7 days post-injection.
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