LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):4 Hum Brain Mapp. 2016 23-Feb;():. 10.1002/hbm.23224What this means for my practice?
These findings suggest that under the influence of LSD, the visual cortex becomes more dependent on intrinsic retinotopic organization. These findings also suggest that the primary visual cortex is involved in the processing of eyes-closed psychedelic imagery. With eyes closed, LSD may be influencing the early visual system to behave as if it were seeing spatially localized visual inputs. Future studies must examine the specific regional sources of eyes-closed psychedelic imagery and associations between the subjective quality of psychedelic imagery and changes in brain activity. The results are limited by the small sample size.
Study Summary
Twenty healthy subjects underwent a placebo-controlled, within-subjects study to examine the effects of LSD on spatially organized activity in the visual cortex by examining the resting-state functional connectivity (RSFC) on visual cortex patches with retinotopic representation. Subjects received LSD and placebo at least two weeks apart and completed a series of MRI, MEG and fMRI scans. The difference between RSFC patches with congruent retinotopic specificity and those with incongruent specificity increased significantly under LSD.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
Are you affiliated with one of our partner associations?
Click here to gain complimentary access as part your association member benefits!
0 of 4 monthly FREE articles unlocked
