Altered network hub connectivity after acute LSD administration
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(12):5 Neuroimage Clin. 2018 23-Feb;():. 10.1016/j.nicl.2018.03.005What this means for my practice?
The findings of decreased functional connectivity (FC) within resting state networks are replicated from previous findings. These LSD-induced effects however, lacked associations with subjective drug effects, questioning the relevance of these LSD-induced alterations. The finding of widely increased between-network FC was inconsistent with previous findings. The findings of increased FC between networks and subcortical and cortical hub structures are consistent with previous findings in psychosis pathological states. These findings may also explain the improvements in mental diseases after hallucinogen administration. The results are limited by the small sample size and the use of fMRI as an indirect measure for neuronal activity.
Study Summary
Twenty healthy subjects underwent a double-blind, randomized, placebo-controlled, cross-over study to examine the effects of LSD on functional connectivity of resting state networks. Subjects received 100 micrograms of LSD and placebo and underwent fMRI to assess resting state brain activity. LSD significantly decreased functional connectivity within visual, sensorimotor, auditory networks and the default mode network. There was increased connectivity between networks and subcortical and cortical hub structures.
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