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The findings of decreased functional connectivity (FC) within resting state networks are replicated from previous findings. These LSD-induced effects however, lacked associations with subjective drug effects, questioning the relevance of these LSD-induced alterations. The finding of widely increased between-network FC was inconsistent with previous findings. The findings of increased FC between networks and subcortical and cortical hub structures are consistent with previous findings in psychosis pathological states. These findings may also explain the improvements in mental diseases after hallucinogen administration. The results are limited by the small sample size and the use of fMRI as an indirect measure for neuronal activity.