Liposomal vs Plain Bupivacaine for Interscalene Block in Rotator Cuff Repair
Interscalene nerve block with plain bupivacaine versus liposomal bupivacaine for arthroscopic rotator cuff repair: A randomized controlled trial.
Saudi J Anaesth . 2025 Apr-Jun;19(2):243-250Forty-one patients undergoing arthroscopic rotator cuff repair (ARCR) were randomized to receive an interscalene block with liposomal bupivacaine (LB) (n=18) or plain bupivacaine (PB) (n=23). The primary outcome was worst VAS pain with movement on postoperative day (POD) 2. Secondary outcomes included pain scores (rest/movement) and opioid use (MME) in PACU and on POD 1, 3, and 7, plus adverse events; outcomes were assessed through POD 7. Overall, the results of the study revealed no significant between-group differences for the primary endpoint (adjusted P=0.55) or for averaged POD1–3 pain at rest and with movement, nor for opioid consumption POD1–3, with daily measures similarly nonsignificant. In short, LB did not improve pain or reduce opioids versus PB in ARCR through 7 days.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
0 of 4 monthly FREE articles unlocked
