A prospective, randomized trial of liposomal bupivacaine compared to conventional bupivacaine on pain control and postoperative opioid use in adults receiving adductor canal blocks for total knee arthroplasty.
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2024;12(16):2 Arthroplasty . 2024 Feb 1;6(1):6.What this means for my practice?
The key takeaway is that while liposomal bupivacaine did not reduce pain scores compared to conventional bupivacaine, it significantly decreased opioid consumption in the postoperative period following total knee arthroplasty. Clinically, this suggests that liposomal bupivacaine can be a valuable option to reduce opioid use in TKA patients. One limitation of the study is that it did not explore long-term outcomes beyond 72 hours, such as functional recovery or readmission rates.
Study Summary
Eighty patients undergoing total knee arthroplasty were randomized to receive either liposomal bupivacaine (n=40) or conventional bupivacaine (n=40) in adductor canal blocks. The primary outcome of interest was pain scores within 72 hours postoperatively. Secondary outcomes included opioid consumption and length of hospital stay. Outcomes were assessed over a period of 72 hours post-surgery. Overall, the results of the study revealed that patients in the liposomal bupivacaine group had significantly lower opioid consumption during the 72-hour period, but there were no significant differences in pain scores or hospital stay between the groups. The findings suggest that liposomal bupivacaine may help reduce opioid use without impacting pain control or hospital length of stay.
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