ACE Report Cover
IV TXA Reduces Blood Loss & Transfusion Rate in Hip Fracture Surgery
Language
Download
Cite
+ Favorites
Language
Download
Cite
+ Favorites
AceReport Image
PERI-OPERATIVE
IV TXA Reduces Blood Loss & Transfusion Rate in Hip Fracture Surgery .
Verified
This report has been verified by one or more authors of the original publication.

Single dose of tranexamic acid effectively reduces blood loss and transfusion rates in elderly patients undergoing surgery for hip fracture: a randomized controlled trial

Bone Joint J. 2021 Mar;103-B(3): 442-448.

One hundred and sixty-five elderly patients scheduled to receive a cemented hemiarthroplasty for a subcapital hip fracture (n=64) or intramedullary nailing procedure for intertrochanteric fracture (n=101) were randomized to receive intravenous tranexamic acid (TXA; n=77) or a normal saline placebo (n=88) for the reduction of blood loss and transfusion rates. Outcomes of interest included total blood loss, total hemoglobin loss, transfusion rate, number of transfused red blood cell units, the incidence of mortality, and the incidence of life-threatening complications. Transfusions, blood loss, and hemoglobin loss were measured up to the 4th post-operative day. Results revealed statistically significantly lower total blood loss and total hemoglobin loss in the TXA group compared to the placebo group (p>0.05 for all). However, in the subgroup analysis by fracture type, only in the intertrochanteric fracture group was the total blood loss and total hemoglobin loss statistically significantly lower in the TXA group (p>0.05 for all). In the overall analysis, transfusion rate and mean transfused red blood cell units were statistically significantly lower in the TXA group compared to the placebo group (p=0.035). Two deaths in the TXA group and 1 death in the placebo group were recorded. No cases of life-threatening complications were seen in the immediate post-operative period.

Unlock the Full ACE Report

You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now

Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics

Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics

Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions

Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics

Or upgrade today and gain access to all OrthoEvidence
content for as little as $1.99 per week.
0 of 4 monthly FREE articles unlocked
You've reached your limit of 4 free articles views this month

Access to OrthoEvidence for as little as $1.99 per week.

Stay connected with latest evidence. Cancel at any time.
  • Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
  • Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
  • Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Upgrade
Welcome Back!
Forgot Password?
Start your FREE trial today!

Account will be affiliated with


OR
Forgot Password?

OR
Please check your email

If an account exists with the provided email address, a password reset email will be sent to you. If you don't see an email, please check your spam or junk folder.

For further assistance, contact our support team.

Translate ACE Report

OrthoEvidence utilizes a third-party translation service to make content accessible in multiple languages. Please note that while every effort is made to ensure accuracy, translations may not always be perfect.

Cite this ACE Report

OrthoEvidence. IV TXA Reduces Blood Loss & Transfusion Rate in Hip Fracture Surgery. ACE Report. 2021;24(1):2. Available from: https://myorthoevidence.com/AceReport/Show/iv-txa-reduces-blood-loss-transfusion-rate-in-hip-fracture-surgery

Copy Citation
Please login to enable this feature

To access this feature, you must be logged into an active OrthoEvidence account. Please log in or create a FREE trial account.

Premium Member Feature

To access this feature, you must be logged into a premium OrthoEvidence account.

Share this ACE Report