IV and Intra-Articular TXA vs. Epsilon-Aminocaproic Acid in Primary Total Knee Arthroplasty .
Combination of Intravenous and Intra-Articular Application of Tranexamic Acid and Epsilon-Aminocaproic Acid in Primary Total Knee Arthroplasty: A Prospective Randomized Controlled Trial.
Orthop Surg. 2023 Mar;15(3): 687-694.181 patients with end-stage knee osteoarthritis scheduled to receive a total knee arthroplasty were randomized to receive intravenous and intra-articular tranexamic acid (n=90) or epsilon-aminocaproic acid (n=91). The primary outcomes of interest were total blood loss, transfusion rate, and hemoglobin drop. Secondary outcomes of interest included postoperative length of stay and complications. The tranexamic acid group reported significantly less blood loss, a shorter length of stay, and a smaller hemoglobin drop compared to the epsilon-aminocaproic acid group. However, the rate of nausea and vomiting was significantly higher in the tranexamic acid group.
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