The Efficacy Comparison of Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty at Different Dosage Time

Este estudo foi identificado como tendo um impacto potencialmente elevado. A métrica de Alto Impacto da OE, baseada em IA, estima a influência que um artigo poderá ter, integrando sinais da revista em que foi publicado e do conteúdo científico do próprio artigo. Desenvolvido com recurso ao mais avançado processamento de linguagem natural, o modelo High Impact da OE prevê com maior precisão o desempenho futuro de um estudo em termos de citações do que o fator de impacto da revista por si só. Isto permite o reconhecimento precoce de investigação clinicamente significativa e ajuda os leitores a concentrarem-se nos artigos com maior probabilidade de moldar a prática futura.

180 patients undergoing total knee arthroplasty were included in this trial to evaluate the effect that timing of tranexamic acid administration has on blood loss. Patients were randomized to receive 30mg/kg of tranexamic acid infused intravenously 15 minutes before tourniquet inflation, 15 min after tourniquet inflation, at tourniquet deflation, or to a control that did not receive tranexamic acid. Total blood loss and transfusion rate were significantly reduced in the group of patients that received tranexamic acid 15 minutes prior to tourniquet inflation compared to the three other groups. Patients who received tranexamic acid 15 minutes after tourniquet inflation or at tourniquet deflation also demonstrated a significant reduction in total blood loss and transfusion rate compared to patients who did not receive tranexamic acid. The results of this study suggest that tranexamic acid infusion prior to tourniquet inflation may provide optimal reductions in blood loss and transfusion rate in patients undergoing total knee arthroplasty.