The Efficacy Comparison of Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty at Different Dosage Time

この研究はハイインパクトの可能性があります。 OEのAI駆動型ハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文が持つ可能性の高い影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することが可能になり、読者は将来の診療を形成する可能性が最も高い論文に集中することができます。

180 patients undergoing total knee arthroplasty were included in this trial to evaluate the effect that timing of tranexamic acid administration has on blood loss. Patients were randomized to receive 30mg/kg of tranexamic acid infused intravenously 15 minutes before tourniquet inflation, 15 min after tourniquet inflation, at tourniquet deflation, or to a control that did not receive tranexamic acid. Total blood loss and transfusion rate were significantly reduced in the group of patients that received tranexamic acid 15 minutes prior to tourniquet inflation compared to the three other groups. Patients who received tranexamic acid 15 minutes after tourniquet inflation or at tourniquet deflation also demonstrated a significant reduction in total blood loss and transfusion rate compared to patients who did not receive tranexamic acid. The results of this study suggest that tranexamic acid infusion prior to tourniquet inflation may provide optimal reductions in blood loss and transfusion rate in patients undergoing total knee arthroplasty.