Comparison of preemptive and preventive intravenous acetaminophen on opioid consumption in pediatrics undergoing posterior spinal fusion surgery: a randomized controlled trial.

研究概要

Ninety-nine patients aged 11–20 years undergoing posterior spinal fusion for adolescent idiopathic scoliosis were randomized into three groups: preemptive IV acetaminophen administration (n=33), preventive IV acetaminophen administration (n=33), and placebo (n=33). The primary outcome was cumulative opioid consumption in the first 24 hours postoperatively. Secondary outcomes included opioid consumption at 48 hours, pain scores, adverse events, and recovery parameters. Overall, the preventive group had significantly lower opioid consumption (52.23 mg) compared to the placebo group (66.70 mg). However, there were no significant differences in secondary outcomes across groups.