Low-Dose Short-Term NSAID (Ketorolac) on Cytokine Levels After Orthopaedic Polytrauma .
Does Scheduled Low-Dose Short-Term NSAID (Ketorolac) Modulate Cytokine Levels After Orthopaedic Polytrauma? A Secondary Analysis of a Randomized Clinical Trial.
J Orthop Trauma. 2024 01-Jul;():. 10.1097/BOT.0000000000002807Seventy orthopedic polytrauma patients were randomized to receive either 15 mg of intravenous ketorolac every 6 hours (n=35) or 2 mL of intravenous saline (n=35) for up to 5 inpatient days. The primary outcome was daily cytokine concentrations, including IL-1a, IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2). Secondary outcomes assessed included hospital and ICU length of stay (LOS), pulmonary complications, and acute kidney injury (AKI). Overall, the results showed significantly different mean trends in IL-10 concentrations over time in the ketorolac group (p=0.043) but no significant differences in PGE2, IL-1a, IL-1b, or IL-6 levels between groups. Clinical outcomes, such as LOS and complications, were not significantly different between groups.
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