Intraarticular injection of the stromal vascular fraction for the treatment of knee osteoarthritis a prospective randomized controlled clinical trial.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

66 patients with unilateral knee osteoarthritis (KOA) were enrolled in a double-blind, randomized controlled trial and were randomized in a 1:1:1 ratio to conventional rehabilitation (control) alone, stromal vascular fraction (SVF) injection alone, or stromal vascular fraction injection combined with conventional rehabilitation (SVF + control). During follow-up, 1 patient in the control group discontinued treatment, 2 patients in the SVF group were lost to follow-up, and 1 patient in the combination group was lost to follow-up, resulting in 62 patients included in the final analysis. The primary outcomes of interest were pain assessed by visual analog scale (VAS) and knee symptoms assessed by the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain, stiffness, and function subscales. Secondary outcomes included knee range of motion (ROM) and treatment-related complications. Outcomes were assessed at baseline, 7 days, 1 month, 6 months, and 12 months. Overall, the results of the study demonstrated that both SVF-treated groups had significantly greater and sustained improvements in pain, stiffness, function, and ROM compared with conventional rehabilitation alone, with benefits continuing to increase through 12 months and no significant safety concerns.