Improvement in pain and function in ankle osteoarthritis patients with sodium hyaluronate .
Sodium Hyaluronate in the Treatment of Osteoarthritis of the Ankle: A Controlled, Randomized, Double-Blind Pilot Study
J Bone Joint Surg Am. 2006 Feb;88(2):295-30220 patients with osteoarthritis of the ankle were randomised in this preliminary study to receive a sodium hyaluronate intervention or a phosphate-buffered saline solution for the treatment of osteoarthritic pain. The primary outcome was based on the ankle osteoarthritis score. Results indicated that a sodium hyaluronate intervention administered intra-articularly once a week for 5 weeks may improve pain and function.
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