Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum

تم تحديد هذه الدراسة على أنها ذات تأثير كبير محتمل. يقدّر مقياس التأثير العالي الذي يعتمد على الذكاء الاصطناعي من OE التأثير المحتمل لورقة بحثية ما من خلال دمج إشارات من كل من المجلة التي نُشرت فيها والمحتوى العلمي للمقالة نفسها. تم تطوير نموذج OE High Impact باستخدام أحدث تقنيات معالجة اللغة الطبيعية، ويتنبأ نموذج OE High Impact بدقة أكبر بأداء الاقتباس المستقبلي للدراسة أكثر من معامل تأثير المجلة وحده. وهذا يتيح التعرف المبكر على الأبحاث ذات المغزى السريري ويساعد القراء على التركيز على المقالات التي من المرجح أن تشكل الممارسة المستقبلية.

ملخص الدراسة

Four healthy participants were included in this double-blind, placebo-controlled study examining the dose-related effects of inhaled salvinorin A. Participants were administered ascending doses of salvinorin A (0.375 - 21 μg/kg) or placebo across twenty sessions with a washout period of at least one day between sessions. Placebo was administered once every five sessions for a total of four sessions, therefore participants received the treatment drug in sixteen of the twenty sessions. Physiological drug effects were assessed by measuring heart rate and blood pressure, as well as resting and kinetic tremor severity on a 5-point scale. Drug strength was assessed using participant ratings on an 11-point scale and subjective drug effects were assessed using the Hallucinogen Rating Scale (HRS) and the Mysticism Scale. Salvinorin A did not significantly increase heart rate or blood pressure. While subjective reports of drug effects did show some similarities to classic hallucinogens, including mystical-type effects, participant experiences were unique and often characterized by disruptions in vestibular and interoceptive signals and unusual recurring themes, such as revisiting childhood memories. Despite these intense subjective effects, participants were largely behaviorally inactive.