Extended-release metoprolol in the prevention of CV complications in non-cardiac surgery .
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Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial
Lancet. 2008 May 31;371(9627):1839-47. doi: 10.1016/S0140-6736(08)60601-7. Epub 2008 May 12.9298 patients with, or at risk of, atherosclerotic disease and undergoing non-cardiac surgery, were randomized to receive perioperative administration of either extended-release metoprolol or a placebo equivalent. The purpose of this study was to compare these two groups with respect to rates of cardiovascular complications over a period of 30 postoperative days. Results indicated that, although the metoprolol group experienced significantly lower rates of fatal and non-fatal myocardial infarction, cardiac revascularisation and new clinically-significant atrial fibrillation, the proportion of patients who either died (total mortality), suffered a stroke or experienced clinically-significant hypotension and bradycardia was significantly lower in the placebo group.
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