Efficacy evaluation of highly purified intra-articular hyaluronic acid vs hylan G-F20 .
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Efficacy evaluation of highly purified intra-articular hyaluronic acid (Sinovial(®)) vs hylan G-F20 (Synvisc(®)) in the treatment of symptomatic knee osteoarthritis. A double-blind, controlled, randomized, parallel-group non-inferiority study.
. 2011 ;():.
381 patients with knee osteoarthritis (OA) were randomized to receive intra-articular injections with either Synovail (highly purified intra-articular hyaluronic acid) or Synvisc (hylan G-F20) once a week for three weeks. This double blinded randomized trial examined the efficacy and non-inferiority of Synovial treatment in patients with OA of the knee. The results from this study indicate that both treatments provide significant reductions in the WOMAC Index pain sub-scores at 6 months. Comparisons of mean WOMAC Index pain sub-score decreases from baseline between groups indicate that the treatments are equivalent.
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