Efficacy and Safety of General Anesthesia Induction with Ciprofol in Hip Fracture Surgery of Elderly Patients: A Randomized Controlled Trial.

研究概要

Sixty elderly patients aged ≥75 years undergoing hip fracture surgery were randomized to receive either ciprofol (0.3 mg/kg, n=30) or propofol (1.5 mg/kg, n=30) for general anesthesia induction. The primary outcomes of interest were the incidences of severe hypotension and hypotension during the observation period. Secondary outcomes included success rate of induction, additional sedation requirements, loss of consciousness time, change in hypotension, heart rate, adverse events, and frequency of vasoactive drug use. Outcomes were assessed from drug infusion initiation to five minutes post-intubation. Overall, ciprofol showed a lower incidence of severe hypotension (p=0.035) and hypotension (p=0.037) compared to propofol, with more stable blood pressure (ΔMAP 31.4 ± 11.4 vs. 39.6 ± 15.7, p=0.025). The findings suggest ciprofol provides safer hemodynamic profiles than propofol during anesthesia induction in this population.