Effects of psilocybin on time perception and temporal control of behaviour in humans
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2022;10(11):7 J Psychopharmacol. 2007 23-Feb;():. 10.1177/0269881106065859What this means for my practice?
After psilocybin treatment, subjects were limited in their ability to reproduce interval lengths longer than 3 seconds, to synchronize a motor response to intervals longer than 2 seconds and were limited in the ability to slow down the personal tapping tempo. There was no impairment for shorter intervals on the sensorimotor synchronization and reproduction task. Psilocybin also induced working-memory deficits and subjective changes in conscious state. These results indicate the contribution of the serotonin receptor system to the processing of time intervals longer than 2-3 seconds and in the voluntary control of the speed of movement. The results are limited by the small sample size and the use of only healthy subjects.
Study Summary
Twelve healthy subjects underwent a double-blind, placebo-controlled, within-subject study design to test the effects of psilocybin on measures of time perception. The subjects received a placebo, a medium and high dose (115 µg/kg and 250 µg/kg, respectively) of psilocybin on three days, separated by at least two weeks. The tasks used to measure time perception included temporal reproduction of time intervals, sensorimotor synchronization, and personal/maximum tapping speed. Psilocybin significantly decreased the subjects' ability to reproduce interval durations longer than 2.5 seconds, to synchronize to inter-beat intervals longer than 2 seconds and caused subjects to be slower in their personal tapping speed.
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