Effectiveness Of Intra-Articular Vancomycin In Preventing Prosthetic Joint Infections In TKA and THA .
Effectiveness of intra-articular vancomycin in preventing prosthetic joint infections in hip and knee arthroplasty: A systematic review and meta-analysis of RCT's.
J Orthop . 2025 Jan 4:66:25-33.Five randomized controlled trials involving 1485 patients undergoing primary hip or knee arthroplasty were included in this systematic review and meta-analysis comparing intra-articular vancomycin powder with standard prophylaxis alone. Pooled outcomes of interest included prosthetic joint infection rates, adverse drug reactions, and deep vein thrombosis. The infection rate was lower in the intervention group, but this difference was not statistically significant. Adverse events were also similar, and no significant difference was found for deep vein thrombosis. The analysis suggests that while there may be a trend toward a lower infection rate with intra-articular vancomycin, further research with larger sample sizes is needed to confirm these findings.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
0 of 4 monthly FREE articles unlocked
