Effect of Sequential Intravenous and Oral Tranexamic Acid in Total Knee Arthroplasty .
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Effect of Sequential Intravenous and Oral Tranexamic Acid on Hemoglobin Drop After Total Knee Arthroplasty: A Randomized Controlled Trial.
J Bone Joint Surg Am. 2022 Jan 19;104(2): 154-159.One hundred and forty one patients undergoing primary TKA were randomized to receive perioperative intravenous tranexamic acid (IV-TXA) alone (n=48), IV TXA followed by oral TXA for 2 days (2D, n=46) or oral TXA for 5 days (5D, n=47). The primary outcome of interest were maximal drops in hemoglobin, estimated blood loss, transfusion rates and complications. There was no significant differences in hemoglobin drops, estimated blood loss, transfusion rates or postoperative complications.
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