Effect Modifiers of Graded Sensorimotor Retraining for Chronic Low Back Pain: A Secondary Analysis of the RESOLVE Randomized Trial.
Epub Ahead of Print
JAMA Netw Open. 2026 01-Jan:. 10.1001/jamanetworkopen.2025.52787Study Summary
276 patients with chronic non-specific low back pain were randomized to receive graded sensorimotor retraining or sham control with attention procedures. The primary outcomes of interest were pain intensity (NRS) and disability (RMDQ). Secondary analyses examined potential treatment effect modifiers including pain, disability, psychosocial variables, and back perception. Outcomes were assessed at 18 and 52 weeks. Overall, the results of the study revealed limited evidence of meaningful treatment effect modifiers, with most baseline characteristics not influencing outcomes. These findings suggest that graded sensorimotor retraining provides similar benefits across patient subgroups, regardless of baseline characteristics.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
Are you affiliated with one of our partner associations?
Click here to gain complimentary access as part your association member benefits!
0 of 4 monthly FREE articles unlocked
